Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study
PurposeTo determine if the associations among established risk factors and reduced kidney function vary by age.MethodsWe pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort.ResultsHypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertensi... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2013 |
Reihe/Periodikum: | Annals of Epidemiology, vol 23, iss 3 |
Verlag/Hrsg.: |
eScholarship
University of California |
Schlagwörter: | Epidemiology / Biomedical and Clinical Sciences / Public Health / Health Sciences / Atherosclerosis / Cardiovascular / Clinical Research / Hypertension / Aging / Prevention / Kidney Disease / 2.1 Biological and endogenous factors / Aetiology / Renal and urogenital / Adult / Age Factors / Aged / 80 and over / Causality / Cholesterol / LDL / Cohort Studies / Comorbidity / Cross-Sectional Studies / Cystatin C / Female / Humans / Kidney Function Tests / Male / Netherlands / Obesity / Prevalence / Renal Insufficiency / Chronic / Risk Factors / Smoking / United States / Chronic kidney insufficiency / Medical and Health Sciences |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-28747626 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://escholarship.org/uc/item/42p678bt |
PurposeTo determine if the associations among established risk factors and reduced kidney function vary by age.MethodsWe pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort.ResultsHypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertension was associated with a 2.3 (95% confidence interval [CI], 0.1, 4.4), 5.1 (95% CI, 4.1, 6.1), and 6.9 (95%CI, 3.0, 10.4) mL/min/1.73 m(2) lower eGFR in participants 40 to 59, 60 to 79, and at least 80years, respectively (P for interaction < .001). The association of low HDL cholesterol with reduced kidney function was also greater in the older age groups: 4.9 (95% CI, 3.5, 6.3), 7.1 (95% CI, 6.0, 8.3), 8.9 (95% CI, 5.4, 11.9) mL/min/1.73 m(2) (P for interaction < .001). Smoking and obesity were associated with reduced kidney function in participants under 80 years. All estimates of the potential population impact of the risk factors were modest.ConclusionsHypertension, obesity, smoking, and low HDL cholesterol are modestly associated with reduced kidney function in nondiabetics. The associations of hypertension and HDL cholesterol with reduced kidney function seem to be stronger in older adults.