There are several elements that impact individuals' college program selection. Most students choose their college program based on parental influence, often overlooking some aspects such as whether they are fit or interested in the programs. This research focused on finding if there’s a significant relationship between the alignment of students’ programs with their interests and skills to their academic performance. The test was conducted on the 3rd-year students of Holy Cross College enrolled in the year 2021-2022. The researchers conducted the survey on the selected programs of Holy Cross College which is from the Education, Computer Science, Business Management, and Hospitality Management. This study used a quantitative, non-experimental design using a correlational approach. Spearman Rank Correlation, a non-parametric test was used to find the relationships between the alignment of the students and their academic performance. In testing the alignment of the students, the researchers used the Holland Theory. The data show that the obtained value is rs = -0.004 and the critical value is set at 0.206. Failure to pass certain criteria we fail to reject our null hypothesis (rs = -0.004, ρ>0.05). Therefore, we can say that there is no significant relationship between the alignment of students’ programs with their skills and interests, and performance. Whether the student’s programs are aligned or not aligned with their interest and skills they can still have good performance in their chosen programs. Although from the data obtained we can notice that students aligned with their programs have better performance academically.