Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population
Background: In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). Results: In 2027 participants randomly recruited from a Flemish population (51.0 % women; mean age 43.6 years), we genotyped six SNPs in MEOX2 and four in TCF15. Over 15.2 years (median), CHD, myocardial infarction, coronary revascularisation and ischaemic cardiomyopathy occurred in 106, 53, 78 and 22 participant... Mehr ...
Verfasser: |
Yang, Wen-Yi
Petit, Thibault
Thijs, Lutgarde
Zhang, Zhen-Yu
Jacobs, Lotte
Hara, Azusa
Wei, Fang-Fei
Salvi, Erika
Citterio, Lorena
Carpini, Simona Delli
Gu, Yu-Mei
Knez, Judita
Cauwenberghs, Nicholas
Barcella, Matteo
Barlassina, Cristina
Manunta, Paolo
Coppiello, Giulia
Aranguren, Xabier L.
Kuznetsova, Tatiana
Cusi, Daniele
Verhamme, Peter
Luttun, Aernout
Staessen, Jan A. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2015 |
Reihe/Periodikum: |
Yang , W-Y , Petit , T , Thijs , L , Zhang , Z-Y , Jacobs , L , Hara , A , Wei , F-F , Salvi , E , Citterio , L , Carpini , S D , Gu , Y-M , Knez , J , Cauwenberghs , N , Barcella , M , Barlassina , C , Manunta , P , Coppiello , G , Aranguren , X L , Kuznetsova , T , Cusi , D , Verhamme , P , Luttun , A & Staessen , J A 2015 , ' Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population ' , BMC Genetics , vol. 16 , 116 . https://doi.org/10.1186/s12863-015-0272-2 |
Schlagwörter: |
Clinical genetics
/ Coronary heart disease
/ MEOX2
/ Population science
/ TCF15
/ Translational research |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28654884 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://cris.maastrichtuniversity.nl/en/publications/7255cacd-1daa-49ea-9c68-6919016a441c |