The Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction)
Severe, early-onset fetal growth restriction (FGR) due to placental insufficiency is associated with a high risk of perinatal morbidity with long-lasting sequelae and mortality.Placental insufficiency is the result of abnormal formation and function of the placenta(placentation) with inadequate remodelling of the maternal spiral (uteroplacental) arteries.There is currently no therapy available with demonstrated effectiveness. Evidence suggestsSildenafil citrate improves uteroplacental blood flow, growth, and meaningful outcomes. An objective of the study is to evaluate the effectiveness of sil... Mehr ...
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Dokumenttyp: | researchProposal |
Erscheinungsdatum: | 2016 |
Verlag/Hrsg.: |
Zenodo
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Schlagwörter: | Sildenafil / intrauterine growth restrictions (IUGR) / fetal growth restriction (FGR) / Adverse neonatal outcome / randomised controlled trial (RCT) / Phosphodiesterase 5 Inhibitors |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-28640464 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.5281/zenodo.56148 |
Severe, early-onset fetal growth restriction (FGR) due to placental insufficiency is associated with a high risk of perinatal morbidity with long-lasting sequelae and mortality.Placental insufficiency is the result of abnormal formation and function of the placenta(placentation) with inadequate remodelling of the maternal spiral (uteroplacental) arteries.There is currently no therapy available with demonstrated effectiveness. Evidence suggestsSildenafil citrate improves uteroplacental blood flow, growth, and meaningful outcomes. An objective of the study is to evaluate the effectiveness of sildenafil (versus placebo) in achieving healthyperinatal survival.