A paper produced in the frame of the H2020 project 677353 'Innovative Management of Animal GEnetic resources' This study investigates thedifferences in inbreeding depression across thegenome of Dutch Holstein Friesian cattle, by estimating dominance effects and effects of regions of homozygosity(ROH).Genotype (75 k) and phenotype data of 38,792 cows were used. Genome-wide inbreeding depression was observed for all yield, fertility and udder health traits.After correcting for the effect of genome-wide homozygosity, dominanceand ROH variance explained less than 1% of the phenotypic variance for all traits. Furthermore, dominance and ROHeffects were distributed evenly along the genome.These findings suggest that, basedon 75 k SNP data, there is little benefit of accountingfor region-specific inbreeding depression in selection schemes. ; The study was co-funded by the Dutch Ministry of Agriculture, Nature and Food Quality (KB-34-013-002). The authors gratefully acknowledge the Dutch-Flemish cattle improvement cooperative (CRV) for providing pedigree and genotype data.