Genetic analysis of indicators of cholesterol synthesis and absorption: Lathosterol and phytosterols in Dutch twins and their parents
Significant familial aggregation was observed for plasma levels of lathosterol (an indicator of whole-body cholesterol synthesis) and plant sterols campesterol and β-sitosterol (indicators of cholesterol absorption) in 160 Dutch families consisting of adolescent mono- and dizygotic twin pairs and their parents. For lathosterol a moderate genetic heritability in parents and offspring (29%) was found. In addition, shared environment also contributed significantly (37%) to variation in plasma lathosterol concentrations in twin siblings. However, a model with different genetic heritabilities in th... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2003 |
Reihe/Periodikum: | Boomsma , D I , Princen , H M G , Frants , R R , Gevers Leuven , J A & Kempen , H J M 2003 , ' Genetic analysis of indicators of cholesterol synthesis and absorption: Lathosterol and phytosterols in Dutch twins and their parents ' , Twin Research , vol. 6 , no. 4 , pp. 307-314 . https://doi.org/10.1375/136905203322296674 |
Schlagwörter: | /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28636213 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://research.vu.nl/en/publications/5fcbda2e-193d-49b3-bf3e-8e540a1b8ad7 |