Deleterious mutations in the tpo gene associated with familial thyroid follicular cell carcinoma in dutch german longhaired pointers
Familial thyroid cancer originating from follicular cells accounts for 5–15% of all the thyroid carcinoma cases in humans. Previously, we described thyroid follicular cell carcinomas in a large number of the Dutch German longhaired pointers (GLPs) with a likely autosomal recessive inheritance pattern. Here, we investigated the genetic causes of the disease using a combined approach of genome-wide association study and runs of homozygosity (ROH) analysis based on 170k SNP array genotype data and whole-genome sequences. A region 0–5 Mb on chromosome 17 was identified to be associated with the di... Mehr ...
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Dokumenttyp: | article/Letter to editor |
Erscheinungsdatum: | 2021 |
Schlagwörter: | Dog / E-MTAB-10241 / ERP126937 / GWAS / Mutation / PRJEB43017 / TPO / Thyroid carcinoma |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28631922 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://research.wur.nl/en/publications/deleterious-mutations-in-the-tpo-gene-associated-with-familial-th |