Model-based effectiveness and cost-effectiveness of risk-based selection strategies for adjuvant chemotherapy in Dutch stage II colon cancer patients
Background: We aimed to evaluate the cost-effectiveness of risk-based strategies to improve the selection of surgically treated stage II colon cancer (CC) patients for adjuvant chemotherapy. Methods: Using the 'Personalized Adjuvant TreaTment in EaRly stage coloN cancer' (PATTERN) model, we evaluated five selection strategies: (1) no chemotherapy, (2) Dutch guideline recommendations assuming observed adherence, (3) Dutch guideline recommendations assuming perfect adherence, (4) biomarker mutation OR pT4 stage strategy in which patients with MSS status combined with a pT4 stage or a mutation in... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Schlagwörter: | adjuvant chemotherapy / biomarkers / colon cancer / cost-effectiveness / personalized medicine / stage II / Gastroenterology / Journal Article |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28631044 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/442648 |