The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses
During the highly pathogenic avian influenza (HPAI) H7N7 virus outbreak in The Netherlands in 2003, 88 infected persons suffered from mild illnesses, and 1 died of pneumonia. Here, we studied which of the 14 amino acid substitutions observed between the fatal case (FC) virus and a conjunctivitis case (CC) virus determined the differences in virus pathogenicity. In virus-attachment experiments, the CC and FC viruses revealed marked differences in binding to the lower respiratory tract of humans. In a mouse model, the hemagglutinin (HA) gene of the FC virus was a determinant of virus tissue dist... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2007 |
Schlagwörter: | Amino Acid Substitution / Animals / Conjunctivitis / Viral/pathology / Disease Models / Animal / Female / Hemagglutinin Glycoproteins / Influenza Virus/chemistry/*genetics / Humans / Influenza A Virus / H5N1 Subtype/genetics / H7N7 Subtype/*genetics/*pathogenicity / Influenza in Birds/genetics / Influenza / Human/genetics/*pathology / Lung/pathology/virology / Mice / Molecular Sequence Data / Netherlands / Poultry / Reassortant Viruses/genetics/*pathogenicity / Virus Attachment |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28626227 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/15050 |