International audience ; Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm t... Mehr ...
| Verfasser: |
Nersisyan, Lilit
Nikoghosyan, Maria
Francioli, Laurent, C
Menelaou, Androniki
Pulit, Sara, L
Elbers, Clara, C
Kloosterman, Wigard, P
van Setten, Jessica
Nijman, Isaäc, J
Renkens, Ivo
de Bakker, Paul, I W
van Dijk, Freerk
Neerincx, Pieter, B T
Deelen, Patrick
Kanterakis, Alexandros
Dijkstra, Martijn
Byelas, Heorhiy
van der Velde, K, Joeri
Platteel, Mathieu
Swertz, Morris, A
Wijmenga, Cisca
Palamara, Pier, Francesco
Pe’er, Itsik
Ye, Kai
Lameijer, Eric-Wubbo
Moed, Matthijs, H
Beekman, Marian
de Craen, Anton, J M
Suchiman, H, Eka D
Slagboom, P, Eline
Guryev, Victor
Abdellaoui, Abdel
Jan Hottenga, Jouke
Kattenberg, Mathijs
Willemsen, Gonneke
Boomsma, Dorret, I
van Leeuwen, Elisabeth, M
Karssen, Lennart, C
Amin, Najaf
Rivadeneira, Fernando
Isaacs, Aaron
Hofman, Albert
Uitterlinden, André, G
van Duijn, Cornelia, M
van Oven, Mannis
Kayser, Manfred
Vermaat, Martijn
Laros, Jeroen, F J
den Dunnen, Johan, T
van Enckevort, David
Mei, Hailiang
Li, Mingkun
Stoneking, Mark
van Schaik, Barbera, D C
Bot, Jan
Marschall, Tobias
Schönhuth, Alexander
Hehir-Kwa, Jayne, Y
Handsaker, Robert, E
Polak, Paz
Sohail, Mashaal
Vuzman, Dana
Estrada, Karol
Mccarroll, Steven, A
Sunyaev, Shamil, R
Hormozdiari, Fereydoun
Koval, Vyacheslav
Medina-Gomez, Carolina
Oostra, Ben
Veldink, Jan, H
van den Berg, Leonard, H
Pitts, Steven, J
Potluri, Shobha
Sundar, Purnima
Cox, David, R
de Knijff, Peter
Li, Qibin
Li, Yingrui
Du, Yuanping
Chen, Ruoyan
Cao, Hongzhi
Wang, Jun
Li, Ning
Cao, Sujie
Bovenberg, Jasper, A
van Ommen, Gert-Jan B
Arakelyan, Arsen |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2019 |
| Verlag/Hrsg.: |
HAL CCSD
|
| Schlagwörter: |
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
/ [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28624935 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cnrs.hal.science/hal-04604758 |
