Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy
Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers and cognitive symptoms. We included (pre)symptomatic D-CAA mutation-carriers and calculated PSMD from diffusion-MRI data. Associations between PSMD-levels, cognitive performance and CAA-related MRI-markers were assessed with linear regression models. We included 59 participants (25/34 presymptomatic/sym... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2024 |
Reihe/Periodikum: | Journal of Cerebral Blood Flow & Metabolism ; ISSN 0271-678X 1559-7016 |
Verlag/Hrsg.: |
SAGE Publications
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Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28621161 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1177/0271678x241261771 |