Long-Term Natural Course of Small Nonfunctional Pancreatic Neuroendocrine Tumors in MEN1-Results From the Dutch MEN1 Study Group

Background: Pancreatic neuroendocrine tumors (pNETs) are highly prevalent in patients with multiple endocrine neoplasia type 1 (MEN1), and metastatic disease is an important cause of MEN1-related mortality. Especially small nonfunctional (NF) pNETs pose a challenge to the treating physician and more information is needed regarding their natural course. We assessed longterm natural history of small NF-pNETs and its modifiers in the Dutch MEN1 population. Patients and Methods: Retrospective longitudinal observational cohort study of patients with small (, 2 cm) NF-pNETs from the Dutch national M... Mehr ...

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Verfasser: Pieterman, Carolina R. C.
de Laat, Joanne M.
Twisk, Jos W. R.
van Leeuwaarde, Rachel S.
de Herder, Wouter W.
Dreijerink, Koen M. A.
Hermus, Ad R. M. M.
Dekkers, Olaf M.
van der Horst-Schrivers, Anouk N. A.
Drent, Madeleine L.
Bisschop, Peter H.
Havekes, Bastiaan
Rinkes, Inne H. M. Borel
Vriens, Menno R.
Valk, Gerlof D.
Dokumenttyp: Artikel
Erscheinungsdatum: 2017
Reihe/Periodikum: Pieterman , C R C , de Laat , J M , Twisk , J W R , van Leeuwaarde , R S , de Herder , W W , Dreijerink , K M A , Hermus , A R M M , Dekkers , O M , van der Horst-Schrivers , A N A , Drent , M L , Bisschop , P H , Havekes , B , Rinkes , I H M B , Vriens , M R & Valk , G D 2017 , ' Long-Term Natural Course of Small Nonfunctional Pancreatic Neuroendocrine Tumors in MEN1-Results From the Dutch MEN1 Study Group ' , Journal of Clinical Endocrinology and Metabolism , vol. 102 , no. 10 , pp. 3795-3805 . https://doi.org/10.1210/jc.2017-00372
Schlagwörter: ENDOCRINE NEOPLASIA TYPE-1 / HIGHER RISK / EXPRESSION / COHORT / GTE / MUTATIONS / PHENOTYPE / SURVIVAL / PATHWAY / DISEASE
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28620108
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/bc957505-af16-4843-8bed-be2e6a6f1f37