Trial by Dutch laboratories for evaluation of non-invasive prenatal testing.:Part I-clinical impact
Objective To evaluate the clinical impact of nationwide implementation of genome-wide non-invasive prenatal testing (NIPT) in pregnancies at increased risk for fetal trisomies 21, 18 and 13 (TRIDENT study). Method Women with elevated risk based on first trimester combined testing (FCT >= 1: 200) or medical history, not advanced maternal age alone, were offered NIPT as contingent screening test, performed by Dutch University Medical laboratories. We analyzed uptake, test performance, redraw/failure rate, turn-around time and pregnancy outcome. Results Between 1 April and 1 September 2014, 14... Mehr ...
Verfasser: |
Oepkes, Dick
Page-Christiaens, G. C. (Lieve)
Bax, Caroline J.
Bekker, Mireille N.
Bilardo, Catia M.
Boon, Elles M. J.
Schuring-Blom, G. Heleen
Coumans, Audrey B. C.
Faas, Brigitte H.
Galjaard, Robert-Jan H.
Go, Attie T.
Henneman, Lidewij
Macville, Merryn V. E.
Pajkrt, Eva
Suijkerbuijk, Ron F.
Huijsdens-van Amsterdam, Karin
Van Opstal, Diane
Verweij, E. J. (Joanne)
Weiss, Marjan M.
Sistermans, Erik A. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2016 |
Reihe/Periodikum: |
Oepkes , D , Page-Christiaens , G C , Bax , C J , Bekker , M N , Bilardo , C M , Boon , E M J , Schuring-Blom , G H , Coumans , A B C , Faas , B H , Galjaard , R-J H , Go , A T , Henneman , L , Macville , M V E , Pajkrt , E , Suijkerbuijk , R F , Huijsdens-van Amsterdam , K , Van Opstal , D , Verweij , E J , Weiss , M M , Sistermans , E A & Dutch NIPT Consortium 2016 , ' Trial by Dutch laboratories for evaluation of non-invasive prenatal testing. Part I-clinical impact ' , Prenatal Diagnosis , vol. 36 , no. 12 , pp. 1083-1090 . https://doi.org/10.1002/pd.4945 |
Schlagwörter: |
CONFINED PLACENTAL MOSAICISM
/ MATERNAL PLASMA
/ DOWN-SYNDROME
/ DIAGNOSTIC-PROCEDURES
/ FETAL ANEUPLOIDIES
/ FREE DNA
/ TRISOMY-21
/ NIPT
/ WOMEN
/ NEWBORNS |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28618543 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://hdl.handle.net/11370/0f9679ad-5121-48d4-86f1-8459be79a727 |