S7.3d Environmental surveillance of Aspergillus fumigatus in Dutch agricultural crops
Abstract S7.3 Emergent theories on pathogenic fungal dispersal around the globe, September 23, 2022, 10:30 AM - 12:00 PM Objectives Azole-resistant Aspergillus fumigatus isolates from the environment hamper the treatment of patients suffering from Aspergillus diseases due to cross-resistance with agricultural azoles. Previous work has suggested A. fumigatus likely gains resistance through environmental azole exposure in so-called hotspots. Methods We investigated A. fumigatus resistance at multi-environmental sites including the compost, strawberry, and potatoes, where farmers used azole fungi... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2022 |
Reihe/Periodikum: | Medical Mycology ; volume 60, issue Supplement_1 ; ISSN 1369-3786 1460-2709 |
Verlag/Hrsg.: |
Oxford University Press (OUP)
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Schlagwörter: | Infectious Diseases / General Medicine |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28615608 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1093/mmy/myac072.s7.3d |
Abstract S7.3 Emergent theories on pathogenic fungal dispersal around the globe, September 23, 2022, 10:30 AM - 12:00 PM Objectives Azole-resistant Aspergillus fumigatus isolates from the environment hamper the treatment of patients suffering from Aspergillus diseases due to cross-resistance with agricultural azoles. Previous work has suggested A. fumigatus likely gains resistance through environmental azole exposure in so-called hotspots. Methods We investigated A. fumigatus resistance at multi-environmental sites including the compost, strawberry, and potatoes, where farmers used azole fungicides for crop protection. Results On average 105 A. fumigatus CFU/g was recovered of which roughly half were itraconazole and tebuconazole resistant. Similar tandem repeat-mediated resistance mechanisms were found in colonies cultured from these environmental sites as reported in clinical azole-resistant isolates. Conclusions Our results suggest that not only azole-containing plant-waste material but also other agricultural crops can be hotspots for resistance selection in A. fumigatus and underscores the need to further investigate transmission routes.