Genomewide Linkage in a Large Dutch Family With Intracranial Aneurysms ; Replication of 2 Loci for Intracranial Aneurysms to Chromosome 1p36.11-p36.13 and Xp22.2-p22.32
Background and Purpose— Approximately 2% of the general population harbor intracranial aneurysms. The prognosis after rupture of an intracranial aneurysm is poor; 50% of the patients die as a result of the rupture. Familial occurrence of intracranial aneurysms suggests there are genetic factors involved in the development of such aneurysms. Methods— A large, consanguineous pedigree with 7 of 20 siblings affected by intracranial aneurysms was compiled and a genomewide linkage analysis on this family was performed using Illumina’s single nucleotide polymorphism-based linkage panel IV, which incl... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2008 |
Reihe/Periodikum: | Stroke ; volume 39, issue 4, page 1096-1102 ; ISSN 0039-2499 1524-4628 |
Verlag/Hrsg.: |
Ovid Technologies (Wolters Kluwer Health)
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Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28608924 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1161/strokeaha.107.495168 |