rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2
Background: Cerebral amyloid angiopathy (CAA) is common disorder of the elderly, a prominent comorbidity of Alzheimer's disease, and causes vascular cognitive impairment and dementia. Previously, we generated a transgenic rat model of capillary CAA type-1 that develops many pathological features of human disease. However, a complementary rat model of larger vessel CAA type-2 disease has been lacking. Methods: A novel transgenic rat model (rTg-D) was generated that produces human familial CAA Dutch E22Q mutant amyloid β-protein (Aβ) in brain and develops larger vessel CAA type-2. Quantitative b... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2022 |
| Reihe/Periodikum: | Cerebral Circulation - Cognition and Behavior, Vol 3, Iss , Pp 100133- (2022) |
| Verlag/Hrsg.: |
Elsevier
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| Schlagwörter: | Cerebral amyloid angiopathy / Small vessel disease / Amyloid β protein / Dutch mutation / Transgenic rat / Microbleed / Specialties of internal medicine / RC581-951 / Neurosciences. Biological psychiatry. Neuropsychiatry / RC321-571 |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-28577584 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://doi.org/10.1016/j.cccb.2022.100133 |
