Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study.
peer reviewed ; In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home residents and 1082 vaccinated staff from 69 nursing homes in Belgium, we assessed the proportion having SARS-CoV-2 antibodies approximately two (April 2021), four (June 2021), and six months (August 2021) after a two-dose regimen of the BNT162b2 vaccine. We measured the seroprevalen... Mehr ...
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Dokumenttyp: | journal article |
Erscheinungsdatum: | 2022 |
Verlag/Hrsg.: |
MDPI
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Schlagwörter: | BNT126b2 / COVID-19 vaccination / IgG / IgM / SARS-CoV-2 / elderly / nursing home residents / seroprevalence / BNT162 Vaccine / COVID-19 Vaccines / Antibodies / Viral / Humans / Belgium/epidemiology / Prevalence / Seroepidemiologic Studies / Prospective Studies / Immunization Programs / Nursing Homes / Vaccination / COVID-19/epidemiology / COVID-19/prevention & control / Belgium / COVID-19 / Infectious Diseases / Virology / Human health sciences / Immunology & infectious disease / Sciences de la santé humaine / Immunologie & maladie infectieuse |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28543555 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://orbi.uliege.be/handle/2268/297732 |
peer reviewed ; In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home residents and 1082 vaccinated staff from 69 nursing homes in Belgium, we assessed the proportion having SARS-CoV-2 antibodies approximately two (April 2021), four (June 2021), and six months (August 2021) after a two-dose regimen of the BNT162b2 vaccine. We measured the seroprevalence using SARS-CoV-2 antibody rapid tests and collected socio-demographic and COVID-19 medical data using an online questionnaire. Two months after vaccination (baseline), we found a seroprevalence of 91% (95% CI: 89-93) among vaccinated residents and 99% (95% CI: 98-99) among vaccinated staff. Six months after vaccination, the seroprevalence significantly decreased to 68% (95% CI: 64-72) among residents and to 89% (95% CI; 86-91) among staff (p < 0.001). The seroprevalence was more likely to decrease among infection-naive residents, older residents, or residents with a high care dependency level. These findings emphasize the need for close monitoring of nursing home residents, as a substantial part of this population fails to mount a persistent antibody response after BNT162b2 vaccination.