Incidence and Predictors of Success of Adalimumab Dose Escalation and De-escalation in Ulcerative Colitis: a Real-World Belgian Cohort Study.
BACKGROUND: Adalimumab (ADM) has been shown efficacious in ulcerative colitis (UC). In randomized controlled trials, dose escalation from 40 mg ADM every other week to 40 mg every week was required in 20%-25% of patients within 1 year. Real-life data suggest higher escalation rates. Attempts for dose de-escalation have not been studied yet. We assessed the need for, outcome of, and predictors of dose escalation and de-escalation in a large retrospective cohort of UC patients treated with ADM. METHODS: We included 231 consecutive patients from 10 Belgian centers initiating ADM treatment for act... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2018 |
Verlag/Hrsg.: |
Oxford University Press
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Schlagwörter: | Adalimumab / Adult / Belgium / Colitis / Ulcerative / Drug Administration Schedule / Drug Monitoring / Female / Humans / Logistic Models / Male / Middle Aged / Retrospective Studies / Risk Factors / Treatment Outcome / Tumor Necrosis Factor-alpha / Withholding Treatment |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28537792 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/2078.1/218803 |