Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial.
peer reviewed ; BACKGROUND: Infections with SARS-CoV-2 continue to cause significant morbidity and mortality. Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic strategies in COVID-19, but study outcomes have been conflicting. We sought to study whether blockade of the IL-6 or IL-1 pathway shortened the time to clinical improvement in patients with COVID-19, hypoxic respiratory failure, and signs of systemic cytokine release syndrome. METHODS: We did a prospective, multicentre, open-label, randomised, controlled trial, in hospitalised patients with COVID-19, hypoxia, and si... Mehr ...
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Dokumenttyp: | journal article |
Erscheinungsdatum: | 2021 |
Verlag/Hrsg.: |
Elsevier
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Schlagwörter: | Aged / Antibodies / Monoclonal/therapeutic use / Monoclonal / Humanized/therapeutic use / Belgium / COVID-19/drug therapy / Cytokine Release Syndrome/drug therapy/virology / Female / Ferritins / Humans / Hypoxia / Interleukin-1/antagonists & inhibitors / Interleukin-6/antagonists & inhibitors / Male / Middle Aged / Oxygen / Prospective Studies / Respiratory Insufficiency/drug therapy/virology / SARS-CoV-2 / Treatment Outcome / Human health sciences / Anesthesia & intensive care / Sciences de la santé humaine / Anesthésie & soins intensifs |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28534768 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://orbi.uliege.be/handle/2268/268482 |