A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shock
BackgroundSeptic shock (SS) and cardiogenic shock (CS) are two types of circulatory shock with a different etiology. Several studies have described the molecular alterations in SS patients, whereas the molecular factors involved in CS have been poorly investigated. We aimed to assess in the whole blood of CS and SS patients, using septic patients without shock (SC) as controls, transcriptomic modifications that occur over 1week after ICU admission and are common to the two types of shock.MethodsWe performed whole blood RNA sequencing in 21 SS, 11 CS, and 5 SC. In shock patients, blood samples... Mehr ...
Verfasser: |
Braga, Daniele
Barcella, Matteo
Herpain, Antoine
Aletti, Federico
Kistler, Erik B
Bollen Pinto, Bernardo
Bendjelid, Karim
Barlassina, Cristina |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2019 |
Reihe/Periodikum: |
Critical Care, vol 23, iss 1 |
Verlag/Hrsg.: |
eScholarship
University of California
|
Schlagwörter: |
Biomedical and Clinical Sciences
/ Clinical Research
/ Genetics
/ Hematology
/ 2.1 Biological and endogenous factors
/ Aetiology
/ APACHE
/ Aged
/ 80 and over
/ Alarmins
/ Analysis of Variance
/ Belgium
/ DNA Replication
/ Female
/ Gene Expression Profiling
/ Humans
/ Inflammasomes
/ Intensive Care Units
/ Longitudinal Studies
/ Male
/ Middle Aged
/ Pilot Projects
/ Prospective Studies
/ Receptors
/ Interleukin
/ Pattern Recognition
/ Sequence Analysis
/ RNA
/ Shock
/ Cardiogenic
/ Septic
/ Switzerland
/ Septic shock
/ Cardiogenic shock
/ Critical illness
/ Circulatory shock
/ RNA-Seq
/ PRR
/ Immunoglobulin
/ Medical and Health Sciences
/ Emergency & Critical Care Medicine
/ Health sciences |
Sprache: |
unknown |
Permalink: |
https://search.fid-benelux.de/Record/base-28526379 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
|
https://escholarship.org/uc/item/6q4920kz |