SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule.
Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed in the proximal tubule cells. Whether patients with COVID-19 present specific manifestations of proximal tubule dysfunction remains unknown. To test this, we examined a cohort of 49 patients requiring hospitalization in a large academic hospital in Brussels, Belgium. There was evidence of proximal tubule dysfunction in a subset of patients with COVID-19, as attested by low-molecular-weight proteinuria (70-80%), neutral aminoac... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2020 |
Schlagwörter: | Aged / 80 and over / Belgium / Betacoronavirus / COVID-19 / Case-Control Studies / Coronavirus Infections / Humans / Kidney Tubules / Proximal / Male / Middle Aged / Pandemics / Pneumonia / Viral / SARS-CoV-2 / kidney / renal Fanconi syndrome / severe acute respiratory syndrome |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28522611 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/2078.1/276405 |