Prognostic, predictive abilities and concordance of BCL2 and TP53 protein expression in primary breast cancers and axillary lymph-nodes: A retrospective analysis of the Belgian three arm study evaluating anthracycline vs CMF adjuvant chemotherapy

Given recent data on genetic heterogeneity within and individual's tumor, we investigated if there were differences in the prognostic and predictive abilities of BCL2 and TP53 protein expression in primary breast cancer (TU) and corresponding axillary lymph-nodes (LN). We used patient samples from the adjuvant Belgian three-arm study which randomized between anthracycline containing regimens and traditional CMF. The endpoints analyzed were overall survival (OS), event-free survival (EFS) and interactions between chemotherapy regimens.At a median follow-up of 15.6 years, BCL2 and TP53 (in both... Mehr ...

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Verfasser: Bozovic-Spasojevic, Ivana
Ameye, Lieveke
Paesmans, Marianne
Larsimont, Denis
Di Leo, Angelo
Dolci, Stella
Azambuja, Evandro
Piccart-Gebhart, Martine
Loi, Sherene
Dokumenttyp: Artikel
Erscheinungsdatum: 2014
Schlagwörter: Chirurgie / Adult / Aged / Antibiotics / Antineoplastic -- therapeutic use / Antineoplastic Combined Chemotherapy Protocols -- therapeutic use / Axilla / Breast Neoplasms -- drug therapy -- metabolism -- pathology / Carcinoma / Ductal / Breast -- drug therapy -- metabolism -- pathology / Lobular -- drug therapy -- metabolism -- pathology / Chemotherapy / Adjuvant / Cisplatin -- therapeutic use / Disease-Free Survival / Epirubicin -- therapeutic use / Female / Fluorouracil -- therapeutic use / Humans / Lymph Nodes -- metabolism -- pathology / Methotrexate -- therapeutic use / Middle Aged / Prognosis / Proto-Oncogene Proteins c-bcl-2 -- metabolism / Retrospective Studies / Treatment Outcome / Tumor Markers / Biological -- metabolism / Tumor Suppressor Protein p53 -- metabolism / BCL2 / Biomarkers / Breast cancer / Expression / TP53
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28491105
Datenquelle: BASE; Originalkatalog
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Link(s) : http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/187913