Extended follow up of high-dose melphalan and autologous stem cell transplantation after vincristine, doxorubicin, dexamethasone induction in amyloid light chain amyloidosis of the prospective phase II HOVON-41 study by the Dutch-Belgian Co-operative Trial Group for Hematology Oncology
In a prospective multicenter phase II study, we evaluated the effect of three courses of vincristine, doxorubicin and dexamethasone followed by high-dose melphalan and autologous stem cell transplantation on an intention-to-treat basis. Sixty-nine newly diagnosed patients with amyloid light chain amyloidosis were included between November 2000 and January 2006: 37 men and 32 women with a median age of 56 years, including 46% of patients with cardiac and 22% of patients with involvement of 3 or 4 organs. Initial results presented in 2008 showed a 4-year overall survival rate of 62% among all th... Mehr ...
Verfasser: |
Hazenberg, Bouke P. C.
Croockewit, Alexandra
van der Holt, Bronno
Zweegman, Sonja
Bos, Gerard M. J.
Delforge, Michel
Raymakers, Reinier A. P.
Sonneveld, Pieter
Vellenga, Edo
Wijermans, Pierre W.
von dem Borne, Peter A.
van Oers, Marinus H.
de Weerdt, Okke
Spoelstra, Fokje M.
Lokhorst, Henk M. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2015 |
Reihe/Periodikum: |
Hazenberg , B P C , Croockewit , A , van der Holt , B , Zweegman , S , Bos , G M J , Delforge , M , Raymakers , R A P , Sonneveld , P , Vellenga , E , Wijermans , P W , von dem Borne , P A , van Oers , M H , de Weerdt , O , Spoelstra , F M , Lokhorst , H M & Dutch-Belgian Cooperative Trial Gr 2015 , ' Extended follow up of high-dose melphalan and autologous stem cell transplantation after vincristine, doxorubicin, dexamethasone induction in amyloid light chain amyloidosis of the prospective phase II HOVON-41 study by the Dutch-Belgian Co-operative Trial Group for Hematology Oncology ' , Haematologica , vol. 100 , no. 5 , pp. 677-682 . https://doi.org/10.3324//haematol.2014.119198 |
Schlagwörter: |
PRIMARY SYSTEMIC AMYLOIDOSIS
/ AL AMYLOIDOSIS
/ MULTIPLE-MYELOMA
/ NATRIURETIC PEPTIDE
/ SURVIVAL
/ CYCLOPHOSPHAMIDE
/ LENALIDOMIDE
/ BORTEZOMIB
/ CHEMOTHERAPY
/ MAINTENANCE |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28489702 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://hdl.handle.net/11370/cd527fef-0d5b-4b39-8002-be44b9cf0b49 |