Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands:A nationwide prospective cohort study

Background Vaccines can be less immunogenic in people living with HIV (PLWH), but for SARS-CoV-2 vaccinations this is unknown. In this study we set out to investigate, for the vaccines currently approved in the Netherlands, the immunogenicity and reactogenicity of SARS-CoV-2 vaccinations in PLWH. Methods and findings We conducted a prospective cohort study to examine the immunogenicity of BNT162b2, mRNA-1273, ChAdOx1-S, and Ad26.COV2.S vaccines in adult PLWH without prior COVID-19, and compared to HIV-negative controls. The primary endpoint was the anti-spike SARS-CoV-2 IgG response after mRNA... Mehr ...

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Verfasser: Hensley, Kathryn S.
Jongkees, Marlou J.
Geers, Daryl
GeurtsvanKessel, Corine H.
Mueller, Yvonne M.
Dalm, Virgil A. S. H.
Papageorgiou, Grigorios
Steggink, Hanka
Gorska, Alicja
Bogers, Susanne
den Hollander, Jan G.
Bierman, Wouter F. W.
Gelinck, Luc B. S.
Schippers, Emile F.
Ammerlaan, Heidi S. M.
van der Valk, Marc
van Vonderen, Marit G. A.
Delsing, Corine E.
Gisolf, Elisabeth H.
Bruns, Anke H. W.
Lauw, Fanny N.
Berrevoets, Marvin A. H.
Sigaloff, Kim C. E.
Soetekouw, Robert
Branger, Judith
de Mast, Quirijn
Lammers, Adriana J. J.
Lowe, Selwyn H.
de Vries, Rory D.
Katsikis, Peter D.
Rijnders, Bart J. A.
Brinkman, Kees
Roukens, Anna H. E.
Rokx, Casper
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Hensley , K S , Jongkees , M J , Geers , D , GeurtsvanKessel , C H , Mueller , Y M , Dalm , V A S H , Papageorgiou , G , Steggink , H , Gorska , A , Bogers , S , den Hollander , J G , Bierman , W F W , Gelinck , L B S , Schippers , E F , Ammerlaan , H S M , van der Valk , M , van Vonderen , M G A , Delsing , C E , Gisolf , E H , Bruns , A H W , Lauw , F N , Berrevoets , M A H , Sigaloff , K C E , Soetekouw , R , Branger , J , de Mast , Q , Lammers , A J J , Lowe , S H , de Vries , R D , Katsikis , P D , Rijnders , B J A , Brinkman , K , Roukens , A H E & Rokx , C 2022 , ' Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands : A nationwide prospective cohort study ' , PLoS Medicine , vol. 19 , no. 10 , e1003979 , pp. e1003979 . https://doi.org/10.1371/journal.pmed.1003979
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27624096
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vumc.nl/en/publications/5091c3d0-deb9-48e5-99c4-24f795004439