Cannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve as a mediator to link environmental exposures to health outcomes. We conducted an epigenome-wide association study (EWAS) of peripheral blood-based DNA methylation and lifetime cannabis use (ever vs. never) in a meta-analysis including 9436 participants (7795 European and 1641 African ancestry) from seven cohorts. Accounting for effects of cigarette smoking, our trans-ancestry EWAS meta-analysis revealed four CpG sites significantly associated with lifetime cannabis use at a... Mehr ...
| Verfasser: |
Fang, Fang
Quach, Bryan
Lawrence, Kaitlyn G.
van Dongen, Jenny
Marks, Jesse A.
Lundgren, Sara
Lin, Mingkuan
Odintsova, Veronika V.
Costeira, Ricardo
Xu, Zongli
Zhou, Linran
Mandal, Meisha
Xia, Yujing
Vink, Jacqueline M.
Bierut, Laura J.
Ollikainen, Miina
Taylor, Jack A.
Bell, Jordana T.
Kaprio, Jaakko
Boomsma, Dorret I.
Xu, Ke
Sandler, Dale P.
Hancock, Dana B.
Johnson, Eric O. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2024 |
| Reihe/Periodikum: |
Fang , F , Quach , B , Lawrence , K G , van Dongen , J , Marks , J A , Lundgren , S , Lin , M , Odintsova , V V , Costeira , R , Xu , Z , Zhou , L , Mandal , M , Xia , Y , Vink , J M , Bierut , L J , Ollikainen , M , Taylor , J A , Bell , J T , Kaprio , J , Boomsma , D I , Xu , K , Sandler , D P , Hancock , D B & Johnson , E O 2024 , ' Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use ' , Molecular Psychiatry , vol. 29 , no. 1 , pp. 124-133 . https://doi.org/10.1038/s41380-023-02310-w |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27622943 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/e172d0a6-5236-41f5-bb27-d79cdc835300 |
