To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10 35) and rs9883204 in ADCY5 (P = 7 × 10 15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 dia... Mehr ...
| Verfasser: |
Freathy, R.M.
Mook-Kanamori, D.O.
Sovio, U.
Prokopenko, I.
Timpson, N.J.
Berry, D.J.
Warrington, N.M.
Widen, E.
Hottenga, J.J.
Kaakinen, M.
Lange, L.A.
Bradfield, J.P.
Kerkhof, M.
Marsh, J.A.
Mägi, R.
Chen, C.M.
Lyon, H.N.
Kirin, M.
Adair, L.S.
Aulchenko, Y.S.
Bennett, A.J.
Borja, J.B.
Bouatia-Naji, N.
Charoen, P.
Coin, L.J.M.
Cousminer, D.L.
de Geus, E.J.C.
Deloukas, P.
Elliott, P.
Evans, D.M.
Froguel, P.
Glaser, B.
Groves, C.J.
Hartikainen, A.-L.
Hassanali, N.
Hirschhorn, J.N.
Hofman, A.
Holly, J.M.P.
Hyppönen, E.
Kanoni, S.
Knight, B.A.
Laitinen, J.
Lindgren, C.M.
McArdle, W.L.
O'Reilly, P.F.
Pennell, C.E.
Postma, D.S.
Pouta, A.
Ramasamy, A.
Rayner, N.W.
Ring, S.M.
Rivadeneira, F.
Shields, B.M.
Strachan, D.P.
Surakka, I.
Taanila, A.
Tiesler, C.
Uitterlinden, A.G.
van Duijn, C.M.
Wijga, A.H.
Willemsen, G.
Zhang, H.
Zhao, J.
Wilson, J.F.
Steegers, E.A.P.
Hattersley, A.T.
Eriksson, J.G.
Peltonen, L.
Mohlke, K.L.
Grant, S.F.A.
Hakonarson, H.
Koppelman, G.H.
Dedoussis, G.V.
Heinrich, J.
Gillman, M.W.
Palmer, L.J.
Frayling, T.M.
Boomsma, D.I.
Smith, G.D.
Power, C.
Jaddoe, V.W.V.
Jarvelin, M.-R.
McCarthy, M.I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2010 |
| Reihe/Periodikum: |
Freathy , R M , Mook-Kanamori , D O , Sovio , U , Prokopenko , I , Timpson , N J , Berry , D J , Warrington , N M , Widen , E , Hottenga , J J , Kaakinen , M , Lange , L A , Bradfield , J P , Kerkhof , M , Marsh , J A , Mägi , R , Chen , C M , Lyon , H N , Kirin , M , Adair , L S , Aulchenko , Y S , Bennett , A J , Borja , J B , Bouatia-Naji , N , Charoen , P , Coin , L J M , Cousminer , D L , de Geus , E J C , Deloukas , P , Elliott , P , Evans , D M , Froguel , P , Glaser , B , Groves , C J , Hartikainen , A-L , Hassanali , N , Hirschhorn , J N , Hofman , A , Holly , J M P , Hyppönen , E , Kanoni , S , Knight , B A , Laitinen , J , Lindgren , C M , McArdle , W L , O'Reilly , P F , Pennell , C E , Postma , D S , Pouta , A , Ramasamy , A , Rayner , N W , Ring , S M , Rivadeneira , F , Shields , B M , Strachan , D P , Surakka , I , Taanila , A , Tiesler , C , Uitterlinden , A G , van Duijn , C M , Wijga , A H , Willemsen , G , Zhang , H , Zhao , J , Wilson , J F , Steegers , E A P , Hattersley , A T , Eriksson , J G , Peltonen , L , Mohlke , K L , Grant , S F A , Hakonarson , H , Koppelman , G H , Dedoussis , G V , Heinrich , J , Gillman , M W , Palmer , L J , Frayling , T M , Boomsma , D I , Smith , G D , Power , C , Jaddoe , V W V , Jarvelin , M-R & McCarthy , M I 2010 , ' Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight ' , Nature Genetics , vol. 42 , no. 5 , pp. 430-435 . https://doi.org/10.1038/ng.567 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27622922 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/dccf40d4-38e2-4e3e-8a3a-a63db8e48095 |
