By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta-analysis of nonagenarian cases from the Rotterdam Study, Leiden 85-plus study, and Danish 1905 cohort. Only one of the 62 prioritized SNPs from the GWAS analysis (P<1×10
| Verfasser: |
Deelen, J.
Beekman, M.
Uh, H.W.
Helmer, Q.
Kuningas, M.
Christiansen, L.
Kremer, D.
van der Breggen, R.
Suchiman, H.E.D.
Lakenberg, N.
van den Akker, E.B.
Passtoors, W.M.
Tiemeier, H.
van Heemst, D.
de Craen, A.J.
Rivadeneira, F.
de Geus, E.J.C.
Perola, M.
van der Ouderaa, F.J.
Gunn, D.A.
Boomsma, D.I.
Uitterlinden, A.G.
Christensen, K.
van Duijn, C.M.
Heijmans, B.T.
Houwing-Duistermaat, J.J.
Westendorp, R.G.J.
Slagboom, P.E. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2011 |
| Reihe/Periodikum: |
Deelen , J , Beekman , M , Uh , H W , Helmer , Q , Kuningas , M , Christiansen , L , Kremer , D , van der Breggen , R , Suchiman , H E D , Lakenberg , N , van den Akker , E B , Passtoors , W M , Tiemeier , H , van Heemst , D , de Craen , A J , Rivadeneira , F , de Geus , E J C , Perola , M , van der Ouderaa , F J , Gunn , D A , Boomsma , D I , Uitterlinden , A G , Christensen , K , van Duijn , C M , Heijmans , B T , Houwing-Duistermaat , J J , Westendorp , R G J & Slagboom , P E 2011 , ' Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited ' , Aging Cell , vol. 10 , no. 4 , pp. 686-698 . https://doi.org/10.1111/j.1474-9726.2011.00705.x |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27622739 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/baa58c3c-add3-4634-ae32-5fec92cdce2e |
