Hundreds of variants clustered in genomic loci and biological pathways affect human height

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits1, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait2,3. The large number of loci reveals patterns with impo... Mehr ...

Volltext
Verfasser: Lango Allen, H.
Estrada, K.
Lettre, G.
Berndt, S.I.
Weedon, M.N.
Rivadeneira, F.
Hottenga, J.J.
de Geus, E.J.C.
Willemsen, G.
van Ommen, G.J.B
Martin, N.G.
Montgomery, GW
Boomsma, D.I.
Penninx, B.W.J.H.
van Duijn, C.M.
Peltonen, L.
Visscher, P.M.
Uitterlinden, A.G.
Abecasis, G.R.
Stefansson, H.
Frayling, T.M.
Hirschhorn, J.N.
Dokumenttyp: Artikel
Erscheinungsdatum: 2010
Reihe/Periodikum: Lango Allen , H , Estrada , K , Lettre , G , Berndt , S I , Weedon , M N , Rivadeneira , F , Hottenga , J J , de Geus , E J C , Willemsen , G , van Ommen , G J B , Martin , N G , Montgomery , GW , Boomsma , D I , Penninx , B W J H , van Duijn , C M , Peltonen , L , Visscher , P M , Uitterlinden , A G , Abecasis , G R , Stefansson , H , Frayling , T M & Hirschhorn , J N 2010 , ' Hundreds of variants clustered in genomic loci and biological pathways affect human height ' , Nature , vol. 467 , no. 7317 , pp. 832-838 . https://doi.org/10.1038/nature09410
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27622648
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/a7141a42-01a9-4d2c-b8e2-98f05886dcc8