Skewed X-inactivation is common in the general female population
X-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Skewed X-inactivation is often explained by negative selection of one of the alleles. We demonstrate that imbalanced expression of the paternal and maternal X-chromosomes is common in the general population and that the random nature of the X-inactivation mechanism can be sufficient to explain the imbalance. To this end, we analyzed blood-derived RNA and whole-genome sequencing data from 79 female children and their parents from the Genom... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2019 |
Reihe/Periodikum: | Shvetsova , E , 't Hoen , P A C , Boomsma , D I , Pool , R , van Dongen , J , Hottenga , J J , Willemsen , G & BIOS Consortium 2019 , ' Skewed X-inactivation is common in the general female population ' , European Journal of Human Genetics , vol. 27 , no. 3 , pp. 455-465 . https://doi.org/10.1038/s41431-018-0291-3 |
Schlagwörter: | /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27622636 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://research.vu.nl/en/publications/a52ef3cd-efa1-4e0e-8fd6-2b815add60f4 |