Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition
Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. Objective: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive t... Mehr ...
Verfasser: |
van der Meer, Dennis
Abdellaoui, Abdel
Boomsma, Dorret I
de Geus, Eco J C
den Braber, Anouk
Hottenga, Jouke-Jan
van 't Ent, Dennis
Andreassen, Ole A |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
van der Meer , D , Abdellaoui , A , Boomsma , D I , de Geus , E J C , den Braber , A , Hottenga , J-J , van 't Ent , D , Andreassen , O A & Writing Committee for the ENIGMA-CNV Working Group 2020 , ' Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition ' , JAMA Psychiatry , vol. 77 , no. 4 , pp. 420-430 . https://doi.org/10.1001/jamapsychiatry.2019.3779 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27622634 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/a4f7a66b-2697-4534-9e7a-d2e3b11b45f1 |