Direct and Indirect Genetic Effects on Aggression
Background: Family members resemble each other in their propensity for aggression. In twin studies, approximately 50% of the variance in aggression can be explained by genetic influences. However, if there are genotype-environment correlation mechanisms, such as environmental manifestations of parental and sibling genotypes, genetic influences may partly reflect environmental influences. In this study, we investigated the importance of indirect polygenic score (PGS) effects on aggression. Methods: We modeled the effect of PGSs based on 3 genome-wide association studies: early-life aggression,... Mehr ...
Verfasser: |
van der Laan, Camiel M.
van de Weijer, Steve G.A.
Pool, René
Hottenga, Jouke Jan
van Beijsterveldt, Toos C.E.M.
Willemsen, Gonneke
Bartels, Meike
Nivard, Michel G.
Boomsma, Dorret I. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2023 |
Reihe/Periodikum: |
van der Laan , C M , van de Weijer , S G A , Pool , R , Hottenga , J J , van Beijsterveldt , T C E M , Willemsen , G , Bartels , M , Nivard , M G & Boomsma , D I 2023 , ' Direct and Indirect Genetic Effects on Aggression ' , Biological psychiatry global open science , vol. 3 , no. 4 , pp. 958-968 . https://doi.org/10.1016/j.bpsgos.2023.04.006 |
Schlagwörter: |
Aggression
/ Genetic nurture
/ Indirect genetic effects
/ Polygenic score
/ Transmitted/nontransmitted alleles
/ Within-family
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27622627 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/a2f48b57-d0e1-4cc4-ba93-d147ddb17cc8 |