Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-ri... Mehr ...
Verfasser: |
Graff, Mariaelisa
Scott, Robert A
Justice, Anne E
Young, Kristin L
Feitosa, Mary F
Barata, Llilda
Winkler, Thomas W
Chu, Audrey Y
Mahajan, Anubha
Hadley, David
Xue, Luting
Workalemahu, Tsegaselassie
Heard-Costa, Nancy L
den Hoed, Marcel
Ahluwalia, Tarunveer S
Qi, Qibin
Ngwa, Julius S
Renström, Frida
Quaye, Lydia
Eicher, John D
Hayes, James E
Cornelis, Marilyn
Kutalik, Zoltan
Lim, Elise
Luan, Jian'an
Huffman, Jennifer E
Zhang, Weihua
Zhao, Wei
Griffin, Paula J
Haller, Toomas
Ahmad, Shafqat
Marques-Vidal, Pedro M
Bien, Stephanie
Yengo, Loic
Teumer, Alexander
Smith, Albert Vernon
Kumari, Meena
Harder, Marie Neergaard
Justesen, Johanne Marie
Kleber, Marcus E
Hollensted, Mette
Lohman, Kurt
Huppertz, Charlotte
Willemsen, Gonneke
Hottenga, Jouke Jan
Milaneschi, Yuri
De Moor, Marleen H M
Penninx, Brenda W J H
de Geus, Eco J C
Boomsma, Dorret I |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Graff , M , Scott , R A , Justice , A E , Young , K L , Feitosa , M F , Barata , L , Winkler , T W , Chu , A Y , Mahajan , A , Hadley , D , Xue , L , Workalemahu , T , Heard-Costa , N L , den Hoed , M , Ahluwalia , T S , Qi , Q , Ngwa , J S , Renström , F , Quaye , L , Eicher , J D , Hayes , J E , Cornelis , M , Kutalik , Z , Lim , E , Luan , J , Huffman , J E , Zhang , W , Zhao , W , Griffin , P J , Haller , T , Ahmad , S , Marques-Vidal , P M , Bien , S , Yengo , L , Teumer , A , Smith , A V , Kumari , M , Harder , M N , Justesen , J M , Kleber , M E , Hollensted , M , Lohman , K , Huppertz , C , Willemsen , G , Hottenga , J J , Milaneschi , Y , De Moor , M H M , Penninx , B W J H , de Geus , E J C , Boomsma , D I & CHARGE Consortium 2017 , ' Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults ' , PLoS Genetics , vol. 13 , no. 4 , e1006528 , pp. e1006528 . https://doi.org/10.1371/journal.pgen.1006528 |
Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27622538 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/9224b722-3fb7-4ec0-822e-04002598628e |