Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular dis... Mehr ...

Volltext
Verfasser: Boomsma, Dorret I.
de Geus, Eco J.C.
Hottenga, Jouke Jan
Willemsen, Gonneke
Dokumenttyp: Artikel
Erscheinungsdatum: 2018
Reihe/Periodikum: Boomsma , D I , de Geus , E J C , Hottenga , J J , Willemsen , G & the Million Veteran Program 2018 , ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ' , Nature Genetics , vol. 50 , no. 10 , pp. 1412-1431 . https://doi.org/10.1038/s41588-018-0205-x
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27622306
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/796b34b1-6752-4452-a574-7864fbeb8b3c

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.