Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency
Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenotypes, and reproductive fitness. Most non-neutral variation consists of deleterious alleles segregating at low population frequency due to incessant mutation. To date, studies characterizing selection against deleterious alleles have been based on allele frequency (testing for a relative excess of rare alleles) or ratio of polymorphism to divergence... Mehr ...
Verfasser: |
Kiezun, A.
Pulit, S.L.
Francioli, L.C.
van Dijk, F.J.
Swertz, M.
Boomsma, D.I.
van Duijn, C.M.
Slagboom, P.E.
van Ommen, G.J.B
Wijmenga, C.
Bakker, P.I.W.
Sunyaev, S.R. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2013 |
Reihe/Periodikum: |
Kiezun , A , Pulit , S L , Francioli , L C , van Dijk , F J , Swertz , M , Boomsma , D I , van Duijn , C M , Slagboom , P E , van Ommen , G J B , Wijmenga , C , Bakker , P I W & Sunyaev , S R 2013 , ' Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency ' , PLoS Genetics , vol. 9 , no. 2 , e1003301 . https://doi.org/10.1371/journal.pgen.1003301 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions
/ name=SDG 16 - Peace
/ Justice and Strong Institutions |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27622282 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/74aadacb-7107-45e5-9775-0b9e218a019c |