Sex-stratified Genome-wide Association Studies Including 270000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trai... Mehr ...

Verfasser:	Randall, J.C. Winkler, T.W. Kutalik, Z. Berndt, S.I. Jackson, A.U. Monda, K.L. Kilpeläinen, T.O. Esko, T. Mägi, R. Li, S. Workalemahu, T. Feitosa, M.F. Croteau-Chonka, D.C. Day, F.R. Fall, T. Ferreira, T. Gustafsson, S. Locke, A.E. Mathieson, I. Scherag, A. Vedantam, S. Wood, A.R. Liang, L. Steinthorsdottir, V. Thorleifsson, G. Dermitzakis, E.T. Dimas, A.S. Karpe, F. Min, J.L. Nicholson, G. Clegg, D.J. Person, T. Krohn, J.P. Bauer, S. Buechler, C. Eisinger, K. Bonnefond, A. Froguel, P. Hottenga, J.J. Prokopenko, I. Waite, L.L. Harris, T.B. Smith, A.V. Shuldiner, A.R. McArdle, W.L. Caulfield, M.J. Munroe, P.B. Grönberg, H. Chen, Y.D. Li, G. Beckmann, J.S. Johnson, T. Thorsteinsdottir, U. Teder-Laving, M. Khaw, K.T. Wareham, N.J. Zhao, J.H. Amin, N. Oostra, B.A. Kraja, A.T. Province, M.A. Cupples, L.A. Heard-Costa, N.L. Kaprio, J. Ripatti, S. Surakka, I. Collins, F.S. Saramies, J. Tuomilehto, J. Jula, A. Salomaa, V. Erdmann, J. Hengstenberg, C. Loley, C. Schunkert, H. Lamina, C. Wichmann, H.E. Albrecht, E. Gieger, C. Hicks, A.A. Johansson, A. Pramstaller, P.P. Kathiresan, S. Speliotes, E.K. Penninx, B.W.J.H. Hartikainen, A.L. Järvelin, M.R. Gyllensten, U. Boomsma, D.I. Campbell, H. Wilson, J.F. Chanock, S.J. Farrall, M. Goel, A. Medina-Gomez, C. Rivadeneira, F. Estrada, K. Uitterlinden, A.G. Hofman, A. Zillikens, M.C. den Heijer, M. Kiemeney, L.A. Maschio, A. Hall, P. Tyrer, J. Teumer, A. Völzke, H. Kovacs, P. Tönjes, A. Mangino, M. Spector, T.D. Hayward, C. Rudan, I. Hall, A.S. Samani, N.J. Attwood, A.P. Sambrook, J.G. Hung, J. Palmer, L.J. Lokki, M.L. Sinisalo, J. Boucher, G. Huikuri, H.V. Lorentzon, M. Ohlsson, C. Eklund, N. Eriksson, J.G. Barlassina, C. Rivolta, C. Nolte, I.M. Snieder, H. van der Klauw, M.M. van Vliet-Ostaptchouk, J.V. Gejman, P.V. Shi, J. Jacobs, K.B. Wang, Z. Bakker, S.J. Mateo Leach, I. Navis, G. van der Harst, P. Martin, N.G. Medland, S.E. Montgomery, G.W. Yang, J. Chasman, D.I. Ridker, P.M. Rose, L.M. Lehtimäki, T. Raitakari, O. Absher, D. Iribarren, C. Basart, H. Hovingh, K.G. Hyppönen, E. Power, C. Anderson, D. Beilby, J.P. Hui, J. Jolley, J. Sager, H. Bornstein, S.R. Schwarz, P.E. Kristiansson, K. Perola, M. Lindström, J. Swift, A.J. Uusitupa, M. Atalay, M. Lakka, T.A. Rauramaa, R. Bolton, J.L. Fowkes, G. Fraser, R.M. Price, J.F. Fischer, K. Krjuta Kov, K. Metspalu, A. Mihailov, E. Langenberg, C. Luan, J. Ong, K.K. Chines, P.S. Keinanen-Kiukaanniemie, S. Saaristo, T.E. Edkins, S. Franks, P.W. Hallmans, G. Shungin, D. Morris, A.D. Palmer, C.N.A. Erbel, R. Moebus, S. Nöthen, M.M. Pechlivanis, S. Hveem, K. Narisu, N. Hamsten, A. Humphries, S.E. Strawbridge, R.J. Tremoli, E. Grallert, H. Thorand, B. Illig, T. Koenig, W. Müller-Nurasyid, M. Peters, A. Boehm, B.O. Kleber, M.E. März, W. Winkelmann, B.R. Kuusisto, J. Laakso, M. Arveiler, D. Cesana, G. Kuulasmaa, K. Virtamo, J. Yarnell, J.W. Kuh, D Wong, A. Lind, L. de Faire, U. Gigante, B. Magnusson, P.K.E. Pedersen, N.L. Dedoussis, G. Dimitriou, M. Kolovou, G. Kanoni, S. Stirrups, K. Bonnycastle, L.L. Njolstad, I. Wilsgaard, T. Ganna, A. Rehnberg, E. Hingorani, A.D. Kivimaki, M. Kumari, M. Assimes, T.L. Barroso, I. Boehnke, M. Borecki, I.B. Deloukas, P. Fox, C.S. Frayling, T.M. Groop, L.C. Haritunians, T. Hunter, D. Ingelsson, E. Kaplan, R. Mohlke, K.L. O'Connell, J.R. Schlessinger, D. Strachan, D.P. Stefansson, K. van Duijn, C.M. Abecasis, G.R. McCarthy, M.I. Hirschhorn, J.N. Qi, L. Loos, R.J. Lindgren, C.M. North, K.E. Heid, I.M.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2013
Reihe/Periodikum:	Randall , J C , Winkler , T W , Kutalik , Z , Berndt , S I , Jackson , A U , Monda , K L , Kilpeläinen , T O , Esko , T , Mägi , R , Li , S , Workalemahu , T , Feitosa , M F , Croteau-Chonka , D C , Day , F R , Fall , T , Ferreira , T , Gustafsson , S , Locke , A E , Mathieson , I , Scherag , A , Vedantam , S , Wood , A R , Liang , L , Steinthorsdottir , V , Thorleifsson , G , Dermitzakis , E T , Dimas , A S , Karpe , F , Min , J L , Nicholson , G , Clegg , D J , Person , T , Krohn , J P , Bauer , S , Buechler , C , Eisinger , K , Bonnefond , A , Froguel , P , Hottenga , J J , Prokopenko , I , Waite , L L , Harris , T B , Smith , A V , Shuldiner , A R , McArdle , W L , Caulfield , M J , Munroe , P B , Grönberg , H , Chen , Y D , Li , G , Beckmann , J S , Johnson , T , Thorsteinsdottir , U , Teder-Laving , M , Khaw , K T , Wareham , N J , Zhao , J H , Amin , N , Oostra , B A , Kraja , A T , Province , M A , Cupples , L A , Heard-Costa , N L , Kaprio , J , Ripatti , S , Surakka , I , Collins , F S , Saramies , J , Tuomilehto , J , Jula , A , Salomaa , V , Erdmann , J , Hengstenberg , C , Loley , C , Schunkert , H , Lamina , C , Wichmann , H E , Albrecht , E , Gieger , C , Hicks , A A , Johansson , A , Pramstaller , P P , Kathiresan , S , Speliotes , E K , Penninx , B W J H , Hartikainen , A L , Järvelin , M R , Gyllensten , U , Boomsma , D I , Campbell , H , Wilson , J F , Chanock , S J , Farrall , M , Goel , A , Medina-Gomez , C , Rivadeneira , F , Estrada , K , Uitterlinden , A G , Hofman , A , Zillikens , M C , den Heijer , M , Kiemeney , L A , Maschio , A , Hall , P , Tyrer , J , Teumer , A , Völzke , H , Kovacs , P , Tönjes , A , Mangino , M , Spector , T D , Hayward , C , Rudan , I , Hall , A S , Samani , N J , Attwood , A P , Sambrook , J G , Hung , J , Palmer , L J , Lokki , M L , Sinisalo , J , Boucher , G , Huikuri , H V , Lorentzon , M , Ohlsson , C , Eklund , N , Eriksson , J G , Barlassina , C , Rivolta , C , Nolte , I M , Snieder , H , van der Klauw , M M , van Vliet-Ostaptchouk , J V , Gejman , P V , Shi , J , Jacobs , K B , Wang , Z , Bakker , S J , Mateo Leach , I , Navis , G , van der Harst , P , Martin , N G , Medland , S E , Montgomery , G W , Yang , J , Chasman , D I , Ridker , P M , Rose , L M , Lehtimäki , T , Raitakari , O , Absher , D , Iribarren , C , Basart , H , Hovingh , K G , Hyppönen , E , Power , C , Anderson , D , Beilby , J P , Hui , J , Jolley , J , Sager , H , Bornstein , S R , Schwarz , P E , Kristiansson , K , Perola , M , Lindström , J , Swift , A J , Uusitupa , M , Atalay , M , Lakka , T A , Rauramaa , R , Bolton , J L , Fowkes , G , Fraser , R M , Price , J F , Fischer , K , Krjuta Kov , K , Metspalu , A , Mihailov , E , Langenberg , C , Luan , J , Ong , K K , Chines , P S , Keinanen-Kiukaanniemie , S , Saaristo , T E , Edkins , S , Franks , P W , Hallmans , G , Shungin , D , Morris , A D , Palmer , C N A , Erbel , R , Moebus , S , Nöthen , M M , Pechlivanis , S , Hveem , K , Narisu , N , Hamsten , A , Humphries , S E , Strawbridge , R J , Tremoli , E , Grallert , H , Thorand , B , Illig , T , Koenig , W , Müller-Nurasyid , M , Peters , A , Boehm , B O , Kleber , M E , März , W , Winkelmann , B R , Kuusisto , J , Laakso , M , Arveiler , D , Cesana , G , Kuulasmaa , K , Virtamo , J , Yarnell , J W , Kuh , D , Wong , A , Lind , L , de Faire , U , Gigante , B , Magnusson , P K E , Pedersen , N L , Dedoussis , G , Dimitriou , M , Kolovou , G , Kanoni , S , Stirrups , K , Bonnycastle , L L , Njolstad , I , Wilsgaard , T , Ganna , A , Rehnberg , E , Hingorani , A D , Kivimaki , M , Kumari , M , Assimes , T L , Barroso , I , Boehnke , M , Borecki , I B , Deloukas , P , Fox , C S , Frayling , T M , Groop , L C , Haritunians , T , Hunter , D , Ingelsson , E , Kaplan , R , Mohlke , K L , O'Connell , J R , Schlessinger , D , Strachan , D P , Stefansson , K , van Duijn , C M , Abecasis , G R , McCarthy , M I , Hirschhorn , J N , Qi , L , Loos , R J , Lindgren , C M , North , K E & Heid , I M 2013 , ' Sex-stratified Genome-wide Association Studies Including 270000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits ' , PLoS Genetics , vol. 9 , no. 6 , e1003500 , pp. e1003500 . https://doi.org/10.1371/journal.pgen.1003500
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being / /dk/atira/pure/sustainabledevelopmentgoals/gender_equality / name=SDG 5 - Gender Equality
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-27622161
Datenquelle:	BASE; Originalkatalog
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Link(s) :	https://research.vu.nl/en/publications/5b72d68e-f85a-4cf5-a4e4-cb4e09d20461