Background:The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach.Methods and Findings:We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a Mendelian randomization design. Thirty-six population-based studies of individuals of European descent con... Mehr ...
| Verfasser: |
Fall, T.
Hägg, S.
Mägi, R.
Ploner, A.
Fischer, K.
Horikoshi, M.
Sarin, A.P.
Thorleifsson, G.
Ladenvall, C.
Kals, M.
Kuningas, M.
Draisma, H.H.M.
Ried, J.S.
van Zuydam, N.R.
Huikari, V.
Mangino, M.
Sonestedt, E.
Benyamin, B.
Nelson, C.P.
Rivera, N.V.
Kristiansson, K.
Shen, H.Y.
Havulinna, A.S.
Dehghan, A.
Donnelly, L.A.
Kaakinen, M.
Nuotio, M.L.
Robertson, N.
de Bruijn, R.F.
Ikram, M.A.
Amin, N.
Balmforth, A.J.
Braund, P.S.
Doney, A.S.F.
Döring, A.
Elliott, P.
Esko, T.
Franco, O.H.
Gretarsdottir, S.
Hartikainen, A.L.
Heikkilä, K.
Herzig, K.H.
Holm, H.
Hottenga, J.J.
Hyppönen, E.
Illig, T.
Isaacs, A.
Isomaa, B.
Karssen, L.C.
Kettunen, J.
Koenig, W.
Kuulasmaa, K.
Laatikainen, T.
Laitinen, J.
Lindgren, C.M.
Lyssenko, V.
Läärä, E.
Rayner, N.W.
Männistö, S.
Pouta, A.
Rathmann, W.
Rivadeneira, F.
Ruokonen, A.
Savolainen, M.J.
Sijbrands, E.J.
Small, K.S.
Smit, J.H.
Steinthorsdottir, V.
Syvänen, A.C.
Taanila, A.
Tobin, M.D.
Uitterlinden, A.G.
Willems, S.M.
Willemsen, G.
Witteman, J.
Perola, M.
Evans, A.
Ferrières, J.
Virtamo, J.
Kee, F
Tregouet, D.A.
Arveiler, D.
Amouyel, P.
Ferrario, M.M.
Brambilla, P.
Hall, A.S.
Heath, A.C.
Madden, P.A.F.
Martin, N.G.
Montgomery, G.W.
Whitfield, J.B.
Jula, A.
Knekt, P.
Oostra, B.A.
van Duijn, C.M.
Penninx, B.W.J.H.
Davey Smith, G.
Kaprio, J.
Samani, N.J.
Gieger, C.
Peters, A.
Wichmann, H.E.
Boomsma, D.I.
de Geus, E.J.C.
Tuomi, T.
Power, C.
Hammond, C.J.
Spector, T.D.
Lind, L.
Orho-Melander, M.
Palmer, C.N.A.
Morris, A.D.
Groop, L.
Järvelin, M.R.
Salomaa, V.
Vartiainen, E.
Hofman, A.
Ripatti, S.
Metspalu, A.
Thorsteinsdottir, U.
Stefansson, K.
Pedersen, N.L.
McCarthy, M.I.
Ingelsson, E.
Prokopenko, I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2013 |
| Reihe/Periodikum: |
Fall , T , Hägg , S , Mägi , R , Ploner , A , Fischer , K , Horikoshi , M , Sarin , A P , Thorleifsson , G , Ladenvall , C , Kals , M , Kuningas , M , Draisma , H H M , Ried , J S , van Zuydam , N R , Huikari , V , Mangino , M , Sonestedt , E , Benyamin , B , Nelson , C P , Rivera , N V , Kristiansson , K , Shen , H Y , Havulinna , A S , Dehghan , A , Donnelly , L A , Kaakinen , M , Nuotio , M L , Robertson , N , de Bruijn , R F , Ikram , M A , Amin , N , Balmforth , A J , Braund , P S , Doney , A S F , Döring , A , Elliott , P , Esko , T , Franco , O H , Gretarsdottir , S , Hartikainen , A L , Heikkilä , K , Herzig , K H , Holm , H , Hottenga , J J , Hyppönen , E , Illig , T , Isaacs , A , Isomaa , B , Karssen , L C , Kettunen , J , Koenig , W , Kuulasmaa , K , Laatikainen , T , Laitinen , J , Lindgren , C M , Lyssenko , V , Läärä , E , Rayner , N W , Männistö , S , Pouta , A , Rathmann , W , Rivadeneira , F , Ruokonen , A , Savolainen , M J , Sijbrands , E J , Small , K S , Smit , J H , Steinthorsdottir , V , Syvänen , A C , Taanila , A , Tobin , M D , Uitterlinden , A G , Willems , S M , Willemsen , G , Witteman , J , Perola , M , Evans , A , Ferrières , J , Virtamo , J , Kee , F , Tregouet , D A , Arveiler , D , Amouyel , P , Ferrario , M M , Brambilla , P , Hall , A S , Heath , A C , Madden , P A F , Martin , N G , Montgomery , G W , Whitfield , J B , Jula , A , Knekt , P , Oostra , B A , van Duijn , C M , Penninx , B W J H , Davey Smith , G , Kaprio , J , Samani , N J , Gieger , C , Peters , A , Wichmann , H E , Boomsma , D I , de Geus , E J C , Tuomi , T , Power , C , Hammond , C J , Spector , T D , Lind , L , Orho-Melander , M , Palmer , C N A , Morris , A D , Groop , L , Järvelin , M R , Salomaa , V , Vartiainen , E , Hofman , A , Ripatti , S , Metspalu , A , Thorsteinsdottir , U , Stefansson , K , Pedersen , N L , McCarthy , M I , Ingelsson , E & Prokopenko , I 2013 , ' The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis ' , PLoS Medicine , vol. 10 , no. 6 , e1001474 , pp. e1001474 . https://doi.org/10.1371/journal.pmed.1001474 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27622071 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/49ee3a54-0131-4268-9e3e-b765367780c6 |
