Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression
BACKGROUND: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk for autoimmune diseases, is also associated with risk for depression. METHODS: We fine-mapped the classical MHC (chr6: 29.6-33.1 Mb), imputing 216 human leukocyte antigen (HLA) alleles and 4 complement component 4 (C4) haplotypes in studie... Mehr ...
Verfasser: |
Glanville, Kylie P
Lewis, Cathryn M
Abdellaoui, A.
Dolan, C.V.
Hottenga, Jouke Jan
Jansen, Rick
Mbarek, Hamdi
Middeldorp, C.M.
Milaneschi, Yusplitri
Nivard, Michel G.
Peyrot, Wouter J
Posthuma, Danielle
Willemsen, Gonneke |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
Glanville , K P , Lewis , C M , Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium , Abdellaoui , A , Dolan , C V , Hottenga , J J , Jansen , R , Mbarek , H , Middeldorp , C M , Milaneschi , Y , Nivard , M G , Peyrot , W J , Posthuma , D & Willemsen , G 2020 , ' Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression ' , Biological Psychiatry , vol. 87 , no. 5 , pp. 419-430 . https://doi.org/10.1016/j.biopsych.2019.06.031 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27621827 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/1b26af9f-26bf-4614-ab59-a7c1eb2b7e31 |