Genome-wide analysis of DNA methylation in buccal cells:A study of monozygotic twins and mQTLs
Background: DNA methylation arrays are widely used in epigenome-wide association studies and methylation quantitative trait locus (mQTL) studies. Here, we performed the first genome-wide analysis of monozygotic (MZ) twin correlations and mQTLs on data obtained with the Illumina MethylationEPIC BeadChip (EPIC array) and compared the performance of the EPIC array to the Illumina HumanMethylation450 BeadChip (HM450 array) for buccal-derived DNA. Results: Good-quality EPIC data were obtained for 102 buccal-derived DNA samples from 49 MZ twin pairs (mean age = 7.5 years, range = 1-10). Differences... Mehr ...
| Verfasser: |
Van Dongen, Jenny
Ehli, Erik A.
Jansen, Rick
Van Beijsterveldt, Catharina E.M.
Willemsen, Gonneke
Hottenga, Jouke J.
Kallsen, Noah A.
Peyton, Shanna A.
Breeze, Charles E.
Kluft, Cornelis
Heijmans, Bastiaan T.
Bartels, Meike
Davies, Gareth E.
Boomsma, Dorret I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Van Dongen , J , Ehli , E A , Jansen , R , Van Beijsterveldt , C E M , Willemsen , G , Hottenga , J J , Kallsen , N A , Peyton , S A , Breeze , C E , Kluft , C , Heijmans , B T , Bartels , M , Davies , G E & Boomsma , D I 2018 , ' Genome-wide analysis of DNA methylation in buccal cells : A study of monozygotic twins and mQTLs ' , Epigenetics and Chromatin , vol. 11 , 54 , pp. 1-14 . https://doi.org/10.1186/s13072-018-0225-x |
| Schlagwörter: |
450 k
/ Array
/ Buccal
/ Children
/ DNA methylation
/ EPIC
/ Epigenetics
/ Illumina
/ QTL
/ Twin study
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27621527 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/eae44eb2-c465-4856-85c7-ef3dd30fd719 |
