Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, A... Mehr ...
| Verfasser: |
Dupuis, J.
Langenberg, C.
Prokopenko, I.
Saxena, R.
Soranzo, N.
Jackson, A.U.
Wheeler, E.
Glazer, N.L.
Bouatia-Naji, N.
Gloyn, A.L.
Lindgren, C.M.
Mägi, R.
Morris, A.P.
Randall, J.
Johnson, T.
Hottenga, J.J.
de Geus, E.J.C.
Kaprio, J.
Kyvik, K.O.
Pedersen, N.L.
Perola, M.
Posthuma, D.
Rivadeneira, F.
Uitterlinden, A.G.
Willems van Dijk, K.
van Hoek, M.
Vogelzangs, N.
Willemsen, G.
Witteman, J.C.M.
Zillikens, M.C.
Penninx, B.W.J.H.
Boomsma, D.I.
van Duijn, C.M.
Aulchenko, Y.S.
Waterworth, D.
Vollenweider, P.
Peltonen, L.
Mooser, V.
Abecasis, G.R.
Wareham, N.J.
Sladek, R.
Froguel, P.
Watanabe, R.M.
Meigs, J.B.
Groop, L.C.
Boehnke, M.
McCarthy, M.I.
Florez, J.C.
Barroso, I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2010 |
| Reihe/Periodikum: |
Dupuis , J , Langenberg , C , Prokopenko , I , Saxena , R , Soranzo , N , Jackson , A U , Wheeler , E , Glazer , N L , Bouatia-Naji , N , Gloyn , A L , Lindgren , C M , Mägi , R , Morris , A P , Randall , J , Johnson , T , Hottenga , J J , de Geus , E J C , Kaprio , J , Kyvik , K O , Pedersen , N L , Perola , M , Posthuma , D , Rivadeneira , F , Uitterlinden , A G , Willems van Dijk , K , van Hoek , M , Vogelzangs , N , Willemsen , G , Witteman , J C M , Zillikens , M C , Penninx , B W J H , Boomsma , D I , van Duijn , C M , Aulchenko , Y S , Waterworth , D , Vollenweider , P , Peltonen , L , Mooser , V , Abecasis , G R , Wareham , N J , Sladek , R , Froguel , P , Watanabe , R M , Meigs , J B , Groop , L C , Boehnke , M , McCarthy , M I , Florez , J C & Barroso , I 2010 , ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ' , Nature Genetics , vol. 42 , no. 2 , pp. 105-116 . https://doi.org/10.1038/ng.520 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27620997 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/b70d0a20-81da-45a1-bb02-25b6848bf955 |
