The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy since first proposed in 2003. Multiple meta-analyses combining results from heterogeneous analyses have not settled the issue. To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses on 31 data sets containing 38 802 European ancestry subjects genotyped for 5-HTTLPR and assessed for... Mehr ...
| Verfasser: |
Culverhouse, R C
Saccone, N.L.
Horton, A C
Ma, Y
Anstey, K J
Banaschewski, T.
Burmeister, M.
Cohen-Woods, Sarah
Etain, B.
Fisher, H L
Goldman, N
Guillaume, S
Horwood, J.
Juhasz, G
Lester, K J
Mandelli, L
Middeldorp, C M
Olié, E
Villafuerte, S.
Air, T M
Araya, R.
Bowes, L
Burns, M.R.
Byrne, Enda M
Coffey, J.C.
Coventry, W.L.
Gawronski, K A B
Glei, D
Hatzimanolis, A
Hottenga, J-J
Jaussent, I
Jawahar, C
Jennen-Steinmetz, C
Kramer, J R
Lajnef, M
Little, K
Meyer zu Schwabedissen, H.
Nauck, M.
Nederhof, E.
Petschner, P
Peyrot, Wouter J
Schwahn, C
Sinnamon, G
Stacey, D.
Tian, Y
Toben, C
Van der Auwera, Sandra
Wainwright, N.W.
Wang, J-C
Willemsen, G
Anderson, I M
Arolt, V.
Åslund, C
Bagdy, G
Baune, Bernard T
Bellivier, F.
Boomsma, D I
Courtet, P
Dannlowski, Udo
de Geus, E J C
Deakin, J F W
Easteal, S
Eley, T.C.
Fergusson, D.M.
Goate, A.M.
Gonda, X
Grabe, Hans J
Holzman, C
Johnson, E.O.
Kennedy, D.M.
Laucht, M
Martin, Nicholas G
Munafò, Marcus R
Nilsson, K.W.
Oldehinkel, Albertine J
Olsson, C A
Ormel, J.
Otte, C.
Patton, G C
Penninx, B W J H
Ritchie, K
Sarchiapone, M.
Scheid, J M
Serretti, A
Smit, J H
Stefanis, N C
Surtees, P G
Völzke, H.
Weinstein, M
Whooley, M.A.
Nurnberger, J.I.
Breslau, N.
Bierut, L.J. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Culverhouse , R C , Saccone , N L , Horton , A C , Ma , Y , Anstey , K J , Banaschewski , T , Burmeister , M , Cohen-Woods , S , Etain , B , Fisher , H L , Goldman , N , Guillaume , S , Horwood , J , Juhasz , G , Lester , K J , Mandelli , L , Middeldorp , C M , Olié , E , Villafuerte , S , Air , T M , Araya , R , Bowes , L , Burns , M R , Byrne , E M , Coffey , J C , Coventry , W L , Gawronski , K A B , Glei , D , Hatzimanolis , A , Hottenga , J-J , Jaussent , I , Jawahar , C , Jennen-Steinmetz , C , Kramer , J R , Lajnef , M , Little , K , Meyer zu Schwabedissen , H , Nauck , M , Nederhof , E , Petschner , P , Peyrot , W J , Schwahn , C , Sinnamon , G , Stacey , D , Tian , Y , Toben , C , Van der Auwera , S , Wainwright , N W , Wang , J-C , Willemsen , G , Anderson , I M , Arolt , V , Åslund , C , Bagdy , G , Baune , B T , Bellivier , F , Boomsma , D I , Courtet , P , Dannlowski , U , de Geus , E J C , Deakin , J F W , Easteal , S , Eley , T C , Fergusson , D M , Goate , A M , Gonda , X , Grabe , H J , Holzman , C , Johnson , E O , Kennedy , D M , Laucht , M , Martin , N G , Munafò , M R , Nilsson , K W , Oldehinkel , A J , Olsson , C A , Ormel , J , Otte , C , Patton , G C , Penninx , B W J H , Ritchie , K , Sarchiapone , M , Scheid , J M , Serretti , A , Smit , J H , Stefanis , N C , Surtees , P G , Völzke , H , Weinstein , M , Whooley , M A , Nurnberger , J I , Breslau , N & Bierut , L J 2018 , ' Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression ' , Molecular Psychiatry , vol. 23 , no. 1 , pp. 133-142 . https://doi.org/10.1038/mp.2017.44 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions
/ name=SDG 16 - Peace
/ Justice and Strong Institutions |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27620879 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/a867d0ad-f3ba-415d-8864-2e5179ee0216 |
