Protease inhibitor (Pi) locus, fertility and twinning
In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of t... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 1992 |
| Reihe/Periodikum: | Boomsma , D I , Frants , R R , Bank , R A & Martin , N G 1992 , ' Protease inhibitor (Pi) locus, fertility and twinning ' , Human Genetics , vol. 89 , no. 3 , pp. 329-332 . https://doi.org/10.1007/BF00220552 |
| Schlagwörter: | /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-27620694 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://research.vu.nl/en/publications/90edae9c-b2fe-43b6-a4ea-b2dc5edf0ce7 |
In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of the parents), for which a correlation of 0.2 was observed. Parents of dizygotic twins came from larger families than parents of monozygotic twins, but no effect of Pi type on family size was seen. © 1992 Springer-Verlag.