WHITE MATTER MICROSTRUCTURE AND AMYLOID AGGREGATION IN COGNITIVELY HEALTHY, ELDERLY IDENTICAL TWINS

Background: Lack of effective predictive models and/or treatments for Alzheimer's Disease (AD) has led a growing movement towards better characterization of pre-clinical stages. One currently established biomarker is positron emission tomography (PET) measured amyloid beta load. Here, in a genetically informative population of cognitively healthy, elderly identical twins, we compared this biomarker to a promising new candidate; white matter (WM) integrity measured by diffusion tensor imaging (DTI). Method(s): Eighty-eight genetically identical twin-pairs and 14 individual twins (n=190, mean ag... Mehr ...