The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the heritability of psychiatric diseases. The contribution of a large number of genes to complex traits can be analyzed with genome-wide profiling. In a discovery sample, a genetic risk profile for depression was defined based on a GWA study of 1738 adult cases and 1802 controls. The genetic risk scores were tested... Mehr ...
| Verfasser: |
Demirkan, A.
Penninx, B.W.J.H.
Hek, K.
Wray, N.R.
Amin, N.
Aulchenko, Y.S.
van Dyck, R.
de Geus, E.J.C.
Hofman, A.
Uitterlinden, A.G.
Hottenga, J.J.
Nolen, W.A.
Oostra, B.A.
Sullivan, P.F.
Willemsen, G.
Zitman, F.G.
Tiemeier, H.
Janssens, A.C.J.W.
Boomsma, D.I.
van Duijn, C.M.
Middeldorp, C.M. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2011 |
| Reihe/Periodikum: |
Demirkan , A , Penninx , B W J H , Hek , K , Wray , N R , Amin , N , Aulchenko , Y S , van Dyck , R , de Geus , E J C , Hofman , A , Uitterlinden , A G , Hottenga , J J , Nolen , W A , Oostra , B A , Sullivan , P F , Willemsen , G , Zitman , F G , Tiemeier , H , Janssens , A C J W , Boomsma , D I , van Duijn , C M & Middeldorp , C M 2011 , ' Genetic risk profiles for depression and anxiety in adult and elderly cohorts ' , Molecular Psychiatry , vol. 16 , no. 7 , pp. 773-783 . https://doi.org/10.1038/mp.2010.65 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27620036 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/50cf8731-c508-462f-9a52-6740873647b5 |
