Sex Differences in Genetic Architecture of Complex Phenotypes?

We examined sex differences in familial resemblance for a broad range of behavioral, psychiatric and health related phenotypes (122 complex traits) in children and adults. There is a renewed interest in the importance of genotype by sex interaction in, for example, genome-wide association (GWA) studies of complex phenotypes. If different genes play a role across sex, GWA studies should consider the effect of genetic variants separately in men and women, which affects statistical power. Twin and family studies offer an opportunity to compare resemblance between opposite-sex family members to th... Mehr ...

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Verfasser: Vink, J.M.
Bartels, M.
van Beijsterveldt, C.E.M.
van Dongen, J.
van Beek, J.H.D.A.
Distel, M.A.
de Moor, M.H.M.
Smit, D.J.A.
Minica, C.C.
Ligthart, L.
Geels, L.M.
Abdellaoui, A.
Middeldorp, C.M.
Hottenga, J.J.
Willemsen, G.
de Geus, E.J.C.
Boomsma, D.I.
Dokumenttyp: Artikel
Erscheinungsdatum: 2012
Reihe/Periodikum: Vink , J M , Bartels , M , van Beijsterveldt , C E M , van Dongen , J , van Beek , J H D A , Distel , M A , de Moor , M H M , Smit , D J A , Minica , C C , Ligthart , L , Geels , L M , Abdellaoui , A , Middeldorp , C M , Hottenga , J J , Willemsen , G , de Geus , E J C & Boomsma , D I 2012 , ' Sex Differences in Genetic Architecture of Complex Phenotypes? ' , PLoS ONE , vol. 7 , no. 12 , e47371 . https://doi.org/10.1371/journal.pone.0047371
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27619837
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/3911f363-b65c-4583-9e58-c7d8c7d843f3