Large scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations

Background: Resistance to rodenticides has been reported globally and poses a considerable problem for efficacy of pest control. The most documented resistance to rodenticides in commensal rodents is associated with mutations in the Vkorc1 gene,in particular in codon 139. Resistance to anticoagulant rodenticides has been reported in the Netherlands since 1989. A study from 2013 showed that 25% of 169 Norway rats (Rattus norvegicus) had a mutation at codon 139 of the Vkorc1 gene. To gain insight in the current status of rodenticide resistance amongst R. norvegicus and M. musculus in the Netherl... Mehr ...