In this project the host-pathogen system of potato (Solanum tuberosum) - late blight (Phytophthora infestans) was analysed as a model system to study management of crop-disease interactions. Resistant cultivars play an important role in sustainable management of the disease. We used an agent-based modelling approach to explore the use of resistant cultivars in late blight control. Important processes in the system are farmers’ decision-making and biophysical processes such as potato growth and Phytophthora growth and dispersal within a certain landscape configuration. To get input for model development in-depth interviews with farmers were carried out to identify the factors involved in decision-making. In the cultivar selection process we focus on a trade-of between the yield and the risk of infection. The first results showed that the model is able to represent ecological and social processes related to potato late blight and farmers’ decision-making and their interactions.