Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo-controlled trial

BACKGROUND: Preterm birth is the leading cause of neonatal morbidity and mortality. The recurrence rate of spontaneous preterm birth is high, and additional preventive measures are required. Our objective was to assess the effectiveness of low-dose aspirin compared to placebo in the prevention of preterm birth in women with a previous spontaneous preterm birth. METHODS AND FINDINGS: We performed a parallel multicentre, randomised, double-blinded, placebo-controlled trial (the APRIL study). The study was performed in 8 tertiary and 26 secondary care hospitals in the Netherlands. We included wom... Mehr ...

Verfasser: Landman, Anadeijda J.E.M.C.
de Boer, Marjon A.
Visser, Laura
Nijman, Tobias A.J.
Hemels, Marieke A.C.
Naaktgeboren, Christiana N.
van der Weide, Marijke C.
Mol, Ben W.
van Laar, Judith O.E.H.
Papatsonis, Dimitri N.M.
Bekker, Mireille N.
van Drongelen, Joris
van Pampus, Mariëlle G.
Sueters, Marieke
van der Ham, David P.
Sikkema, J. Marko
Zwart, Joost J.
Huisjes, Anjoke J.M.
van Huizen, Marloes E.
Kleiverda, Gunilla
Boon, Janine
Franssen, Maureen T.M.
Hermes, Wietske
Visser, Harry
de Groot, Christianne J.M.
Oudijk, Martijn A.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Schlagwörter: Adult / Aspirin/administration & dosage / Dose-Response Relationship / Drug / Double-Blind Method / Female / Humans / Netherlands / Obstetric Labor / Premature/prevention & control / Pregnancy / Premature Birth/prevention & control / Journal Article / Multicenter Study / Randomized Controlled Trial / Research Support / Non-U.S. Gov't
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27612805
Datenquelle: BASE; Originalkatalog
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Link(s) : https://dspace.library.uu.nl/handle/1874/446720