High discordance rate in assessing sentinel node positivity in cutaneous melanoma: Expert review may reduce unjustified adjuvant treatment
Introduction: Identification of sentinel node (SN) metastases can set the adjuvant systemic therapy indication for patients with stage III melanoma. Studies re-evaluating the diagnosis of initially positive SN biopsies are scarce. Materials and methods: Dutch patients with melanoma who underwent SN biopsy between 2003 and 2014 were selected from PALGA, the Dutch Pathology Registry. Histopathological slides of SN-positive patients were retrieved for review. A random sample was reassessed by an expert melanoma pathologist. Recurrence-free survival (RFS) of patients who were misclassified (false-... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Schlagwörter: | Adjuvant therapy / Melanoma / Nodal nevus / Pathology / Sentinel / Predictive Value of Tests / Humans / Middle Aged / Male / Unnecessary Procedures / False Positive Reactions / Patient Selection / Netherlands / Clinical Decision-Making / Adult / Female / Registries / Sentinel Lymph Node/pathology / Retrospective Studies / Melanoma/secondary / Reproducibility of Results / Treatment Outcome / Combined Modality Therapy / Skin Neoplasms/pathology / Aged / Sentinel Lymph Node Biopsy / Neoplasm Staging / Observer Variation / Oncology / Cancer Research / Journal Article |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27612672 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/442620 |