Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis
Background: Sequencing studies have pointed to the involvement in schizophrenia of rare coding variants in neuronally expressed genes, including activity-regulated cytoskeleton-associated protein (ARC) and N-methyl-D-aspartate receptor (NMDAR) complexes; however, larger samples are required to reveal novel genes and specific biological mechanisms. Methods: We sequenced 187 genes, selected for prior evidence of association with schizophrenia, in a new dataset of 5207 cases and 4991 controls. Included among these genes were members of ARC and NMDAR postsynaptic protein complexes, as well as volt... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2019 |
Schlagwörter: | Adult / Cohort Studies / Cytoskeletal Proteins/genetics / Humans / Ireland / Middle Aged / Nerve Tissue Proteins/genetics / Netherlands / Neurons/physiology / Receptors / N-Methyl-D-Aspartate/genetics / Risk Factors / Schizophrenia/genetics / Sequence Analysis / DNA / United Kingdom / Voltage-Gated Sodium Channels/genetics / Biological Psychiatry / Journal Article / Research Support / N.I.H. / Extramural / Non-U.S. Gov't |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27611171 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/381159 |