Human prion diseases in the Netherlands (1998-2009): clinical, genetic and molecular aspects
Prion diseases are rare and fatal neurodegenerative disorders that can be sporadic, inherited or acquired by infection. Based on a national surveillance program in the Netherlands we describe here the clinical, neuropathological, genetic and molecular characteristics of 162 patients with neuropathologically confirmed prion disease over a 12-year period (1998–2009). Since 1998, there has been a relatively stable mortality of Creutzfeldt-Jakob disease (CJD) in the Netherlands, ranging from 0.63 to 1.53 per million inhabitants per annum. Genetic analysis of the codon 129 methionine/valine (M/V) p... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2012 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27609936 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/272950 |